Fatteh Education: Metformin for anti-aging? and more...
Quite a few people take metformin because there is a belief that the medication will be the first approved by the FDA for actually slowing down the aging process. The study here indicates that metformin may reduce osteoporosis in COPD patients who take metformin for DM.
TITLE
Lower Prevalence of Osteoporosis in Patients with COPD Taking Anti-Inflammatory Compounds for the Treatment of Diabetes: Results from COSYCONET.
JOURNAL
International journal of chronic obstructive pulmonary disease
DOI
10.2147/COPD.S335029
Author(s)
K Kahnert;RA Jörres;T Lucke;FC Trudzinski;P Mertsch;C Bickert;JH Ficker;J Behr;R Bals;H Watz;T Welte;CF Vogelmeier;P Alter;
Abstract
Background Patients with chronic obstructive pulmonary disease (COPD) often have osteoporosis and diabetes as comorbid conditions. Anti-diabetic medication, including metformin, has protective effects on osteoporosis in experimental studies. We therefore studied whether patients with COPD receiving anti-diabetic medication had a lower osteoporosis prevalence in a large COPD cohort, COSYCONET. Conclusion: In a large COPD cohort, anti-inflammatory diabetes therapy, including metformin, was associated with a lower prevalence of osteoporosis, especially in patients with higher symptoms and exacerbations. These findings suggest a protective effect of common anti-diabetic medication on osteoporosis, possibly as a result of attenuated systemic inflammation.
I think it is reassuring to families to mention that there are many studies that show that palliative care can improve quality of life in terminal patients such as this study on palliative care for lung cancer patients.
TITLE
Association of Palliative Care Use and Setting With Health-care Utilization and Quality of Care at the End of Life Among Patients With Advanced Lung Cancer.
JOURNAL
Chest
DOI
10.1016/j.chest.2020.06.018
Author(s)
KC Vranas;JA Lapidus;L Ganzini;CG Slatore;DR Sullivan
Abstract
BACKGROUND Palliative care is associated with improved survival and quality of life among patients with lung cancer; however, its influence on health-care utilization and quality of care is unclear. RESEARCH QUESTION Is palliative care, and the setting in which it occurs, associated with health-care resource utilization and quality of care among patients with advanced lung cancer?
INTERPRETATION: Palliative care (particularly in outpatient settings) is associated with reduced health-care utilization at the end of life and may improve the quality of care among patients with advanced lung cancer. These findings support the role of palliative care as an important component of comprehensive cancer care and highlight the potential benefits of outpatient palliative care services.
We have many COPD patients who want to continue inhaled corticosteroids after they are admitted to our sdrvices. This study indicates that inhaled corticosteroids increase the risk of pneumonia and that fluticasoe increases the risk of pneumonia more than budesonide.
TITLE
Comparison of Risk of Pneumonia Caused by Fluticasone Propionate versus Budesonide in Chronic Obstructive Pulmonary Disease: A Nationwide Retrospective Cohort Study.
JOURNAL
International journal of chronic obstructive pulmonary disease
DOI
10.2147/COPD.S332151
Author(s)
JH Choi;KB Jeong;YH Park;I Yu;SJ Lee;MK Lee;SH Kim;WY Lee;SJ Yong;JH Lee
Abstract
Introduction: Inhaled corticosteroids (ICSs) play an important role in lowering the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD). However, ICSs are known to increase the risk of pneumonia. Moreover, previous studies have shown that the incidence rate of pneumonia varies depending on the type of ICS. Conclusion: ICS types and doses need to be carefully considered during treatment with ICSs in patients with COPD.